DNA24
24th International Conference
On DNA Computing and
Molecular Programming
Oct. 8-12, 2018
Dates DNA 24 Program & Schedule Speakers Registration & Submission Location & Travel
Speakers
Jinan ยท 2018
Plenary Speakers
Tutorial Speakers
Speakers
Laura Na Liu, Ph. D.


Gold nanocrystal-mediated sliding of doublet DNA origami filaments

  Sliding is a fundamental means of mechanical movements in machinery. In macroscopic systems, double-rack pinion machines employ gears to slide two linear tracks along opposite directions. In microscopic systems, kinesin-5 proteins crosslink and slide apart antiparallel microtubules, promoting spindle bipolarity and elongation during mitosis.

  In this talk, I will show you an artificial nanoscopic analog, in which gold nanocrystals can mediate coordinated sliding of two antiparallel DNA origami filaments powered by DNA fuels. Stepwise and reversible sliding along opposite directions is in situ monitored and confirmed using fluorescence spectroscopy. A theoretical model including different energy transfer mechanisms is developed to understand the observed fluorescence dynamics. Such sliding can also take place in the presence of multiple DNA side-locks that are introduced to inhibit the relative movements. Our work enriches the toolbox of DNA-based nanomachinery, taking one step further toward the vision of molecular nanofactories. 




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